ATPase, H+ transporting, lysosomal V0 subunit a1

ATP6V0A1
Identifiers
Aliases	ATP6V0A1, Atp6v0a1, AA959968, ATP6a1, Atp6n1, Atp6n1a, Atpv0a1, Vpp-1, Vpp1, Stv1, Vph1, a1, ATPase, H+ transporting, lysosomal V0 subunit a1, ATP6N1, ATP6N1A, VPP1, ATPase H+ transporting V0 subunit a1
External IDs	OMIM: 192130; MGI: 103286; HomoloGene: 3795; GeneCards: ATP6V0A1; OMA:ATP6V0A1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.2 Start 42,458,844 bp End 42,522,611 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 D|11 64.04 cM Start 100,900,278 bp End 100,954,545 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe right hemisphere of cerebellum prefrontal cortex cingulate gyrus anterior cingulate cortex Brodmann area 9 anterior pituitary nucleus accumbens C1 segment hypothalamus Top expressed in superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex subiculum cerebellar cortex perirhinal cortex piriform cortex neural layer of retina dorsomedial hypothalamic nucleus entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase binding proton-transporting ATPase activity, rotational mechanism protein binding proton transmembrane transporter activity Cellular component integral component of membrane proton-transporting V-type ATPase, V0 domain phagocytic vesicle membrane Golgi apparatus intracellular membrane-bounded organelle membrane vacuolar proton-transporting V-type ATPase, V0 domain melanosome vacuolar proton-transporting V-type ATPase complex endosome membrane extracellular exosome cytoplasmic vesicle membrane cytoplasmic vesicle cytoplasm cytosol plasma membrane nuclear speck secretory granule membrane ficolin-1-rich granule membrane lysosomal membrane intracellular organelle perinuclear region of cytoplasm Biological process insulin receptor signaling pathway transferrin transport vacuolar proton-transporting V-type ATPase complex assembly toxin transport ion transport ion transmembrane transport ATP synthesis coupled proton transport regulation of macroautophagy vacuolar acidification phagosome acidification neutrophil degranulation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 535 11975 Ensembl ENSG00000033627 ENSMUSG00000019302 UniProt Q93050 Q9Z1G4 RefSeq (mRNA) NM_001130020 NM_001130021 NM_005177 NM_001243049 NM_001243050 NM_001243051 NM_016920 NM_001362636 NM_001362637 NM_001362638 NM_001362639 NM_001362640 NM_001362641 RefSeq (protein) NP_001123492 NP_001123493 NP_005168 NP_001365451 NP_001365452 NP_001365459 NP_001365460 NP_001365461 NP_001365462 NP_001365463 NP_001365464 NP_001365465 NP_001365466 NP_001365467 NP_001365468 NP_001365469 NP_001365470 NP_001365471 NP_001365472 NP_001365473 NP_001365474 NP_001365475 NP_001365476 NP_001365477 NP_001365478 NP_001365479 NP_001365480 NP_001365481 NP_001365483 NP_001365485 NP_001365486 NP_001229978 NP_001229979 NP_001229980 NP_058616 NP_001349565 NP_001349566 NP_001349567 NP_001349568 NP_001349569 NP_001349570 Location (UCSC) Chr 17: 42.46 – 42.52 Mb Chr 11: 100.9 – 100.95 Mb PubMed search
Wikidata
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V-type proton ATPase 116 kDa subunit a isoform 1 is an enzyme that in humans is encoded by the ATP6V0A1 gene.

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. The occurrence of splice variants encoding different protein products has been reported, but the full-length natures of these transcripts have not been determined.

External links

• Human ATP6V0A1 genome location and ATP6V0A1 gene details page in the UCSC Genome Browser.

Further reading

• Finbow ME, Harrison MA (1997). "The vacuolar H+-ATPase: a universal proton pump of eukaryotes". Biochem. J. 324 (3): 697–712. doi:10.1042/bj3240697. PMC 1218484. PMID 9210392.
• Stevens TH, Forgac M (1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annu. Rev. Cell Dev. Biol. 13: 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887.
• Nelson N, Harvey WR (1999). "Vacuolar and plasma membrane proton-adenosinetriphosphatases". Physiol. Rev. 79 (2): 361–85. doi:10.1152/physrev.1999.79.2.361. PMID 10221984. S2CID 1477911.
• Forgac M (1999). "Structure and properties of the vacuolar (H+)-ATPases". J. Biol. Chem. 274 (19): 12951–4. doi:10.1074/jbc.274.19.12951. PMID 10224039.
• Kane PM (1999). "Introduction: V-ATPases 1992-1998". J. Bioenerg. Biomembr. 31 (1): 3–5. doi:10.1023/A:1001884227654. PMID 10340843.
• Wieczorek H, Brown D, Grinstein S, et al. (1999). "Animal plasma membrane energization by proton-motive V-ATPases". BioEssays. 21 (8): 637–48. doi:10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W. PMID 10440860. S2CID 23505139.
• Nishi T, Forgac M (2002). "The vacuolar (H+)-ATPases--nature's most versatile proton pumps". Nat. Rev. Mol. Cell Biol. 3 (2): 94–103. doi:10.1038/nrm729. PMID 11836511. S2CID 21122465.
• Kawasaki-Nishi S, Nishi T, Forgac M (2003). "Proton translocation driven by ATP hydrolysis in V-ATPases". FEBS Lett. 545 (1): 76–85. doi:10.1016/S0014-5793(03)00396-X. PMID 12788495. S2CID 10507213.
• Morel N (2004). "Neurotransmitter release: the dark side of the vacuolar-H+ATPase". Biol. Cell. 95 (7): 453–7. doi:10.1016/S0248-4900(03)00075-3. PMID 14597263. S2CID 17519696.
• Perin MS, Fried VA, Stone DK, et al. (1991). "Structure of the 116-kDa polypeptide of the clathrin-coated vesicle/synaptic vesicle proton pump". J. Biol. Chem. 266 (6): 3877–81. doi:10.1016/S0021-9258(19)67875-0. PMID 1704894.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.