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ARID4B

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ARID4B
Identifiers
AliasesARID4B, BCAA, BRCAA1, RBBP1L1, RBP1L1, SAP180, AT-rich interaction domain 4B
External IDsOMIM: 609696; MGI: 2137512; HomoloGene: 12847; GeneCards: ARID4B; OMA:ARID4B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001206794
NM_016374
NM_031371

NM_194262
NM_198122

RefSeq (protein)

NP_001193723
NP_057458
NP_112739

NP_919238
NP_937755

Location (UCSC)Chr 1: 235.13 – 235.33 MbChr 13: 14.24 – 14.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene.[5][6]

Function

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This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependent SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000054267Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039219Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cao J, Gao T, Stanbridge EJ, Irie R (Aug 2001). "RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis". J Natl Cancer Inst. 93 (15): 1159–65. doi:10.1093/jnci/93.15.1159. PMID 11481388.
  6. ^ a b "Entrez Gene: ARID4B AT rich interactive domain 4B (RBP1-like)".
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Further reading

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