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ARFGEF1

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ARFGEF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARFGEF1, ARFGEP1, BIG1, P200, ADP ribosylation factor guanine nucleotide exchange factor 1
External IDsOMIM: 604141; MGI: 2442988; HomoloGene: 4687; GeneCards: ARFGEF1; OMA:ARFGEF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006421

NM_001102430

RefSeq (protein)

NP_006412

NP_001095900

Location (UCSC)Chr 8: 67.17 – 67.34 MbChr 1: 10.21 – 10.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.[5][6][7]

Function

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ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.[7]

Interactions

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ARFGEF1 has been shown to interact with FKBP2,[8] ARFGEF2[9] and PRKAR1A.[10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000066777Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067851Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Apr 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". The Journal of Biological Chemistry. 274 (18): 12308–15. doi:10.1074/jbc.274.18.12308. PMID 10212200.
  6. ^ Morinaga N, Tsai SC, Moss J, Vaughan M (Nov 1996). "Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain". Proceedings of the National Academy of Sciences of the United States of America. 93 (23): 12856–60. Bibcode:1996PNAS...9312856M. doi:10.1073/pnas.93.23.12856. PMC 24010. PMID 8917509.
  7. ^ a b "Entrez Gene: ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)".
  8. ^ Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M (Mar 2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506". Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2322–7. Bibcode:2003PNAS..100.2322P. doi:10.1073/pnas.2628047100. PMC 151339. PMID 12606707.
  9. ^ Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. Bibcode:2000PNAS...97.2567Y. doi:10.1073/pnas.97.6.2567. PMC 15969. PMID 10716990.
  10. ^ Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1627–32. Bibcode:2003PNAS..100.1627L. doi:10.1073/pnas.0337678100. PMC 149883. PMID 12571360.
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Further reading

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