Synergin gamma

SYNRG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MX7
Identifiers
Aliases	SYNRG, AP1GBP1, SYNG, synergin, gamma, synergin gamma
External IDs	OMIM: 607291; MGI: 1354742; HomoloGene: 105680; GeneCards: SYNRG; OMA:SYNRG - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	37,609,472 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	83,935,404 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; tonsil; ; epithelium of colon; ; sural nerve; ; lymph node; ; islet of Langerhans; ; granulocyte; ; appendix; ; corpus callosum; ; ganglionic eminence;
	Top expressed in
	zygote; ; spermatocyte; ; spermatid; ; muscle of thigh; ; dentate gyrus of hippocampal formation granule cell; ; secondary oocyte; ; granulocyte; ; neural layer of retina; ; ventricular zone; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; AP-1 adaptor complex; Golgi apparatus; membrane;
Biological process	protein transport; intracellular protein transport; endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	11276
	217030
	ENSG00000275066; ENSG00000274047
	ENSMUSG00000034940
	Q9UMZ2
	Q5SV85
NM_001163544; NM_001163545; NM_001163546; NM_001163547; NM_007247;
	NM_080550; NM_198882
	NM_001115009; NM_194341
NP_001157016; NP_001157017; NP_001157018; NP_001157019; NP_009178;
	NP_542117; NP_942583
NP_919322; NP_001392038; NP_001392041; NP_001392042; NP_001392044;
	NP_001392045; NP_001392047; NP_001392050; NP_001392051; NP_001392052
	Wikidata
View/Edit Human	View/Edit Mouse

Synergin gamma also known as AP1 subunit gamma-binding protein 1 (AP1GBP1) is a protein that in humans is encoded by the SYNRG gene.^[5]^[6]

Function

This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene.^[6]

Interactions

AP1GBP1 has been shown to interact with AP1G1^[7]^[8] and SCAMP1.^[9]

References

^ ^a ^b ^c ENSG00000274047 GRCh38: Ensembl release 89: ENSG00000275066, ENSG00000274047 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034940 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Page LJ, Sowerby PJ, Lui WW, Robinson MS (October 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin". J. Cell Biol. 146 (5): 993–1004. doi:10.1083/jcb.146.5.993. PMC 2169493. PMID 10477754.
^ ^a ^b "Entrez Gene: AP1GBP1 AP1 gamma subunit binding protein 1".
^ Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (July 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nat. Struct. Biol. 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876. S2CID 42630285.
^ Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
^ Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC (April 2000). "SCAMP1 function in endocytosis". J. Biol. Chem. 275 (17): 12752–6. doi:10.1074/jbc.275.17.12752. PMID 10777571.

Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlén S, Dumanski JP (1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics. 50 (2): 275–80. doi:10.1006/geno.1998.5289. PMID 9653655.
Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". J. Cell Biol. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088.
Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC (2000). "SCAMP1 function in endocytosis". J. Biol. Chem. 275 (17): 12752–6. doi:10.1074/jbc.275.17.12752. PMID 10777571.
Takatsu H, Yoshino K, Nakayama K (2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nat. Struct. Biol. 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876. S2CID 42630285.
Kent HM, McMahon HT, Evans PR, Benmerah A, Owen DJ (2002). "Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin". Structure. 10 (8): 1139–48. doi:10.1016/S0969-2126(02)00801-8. PMID 12176391.
Mills IG, Praefcke GJ, Vallis Y, Peter BJ, Olesen LE, Gallop JL, Butler PJ, Evans PR, McMahon HT (2003). "EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking". J. Cell Biol. 160 (2): 213–22. doi:10.1083/jcb.200208023. PMC 2172650. PMID 12538641.
Lui WW, Collins BM, Hirst J, Motley A, Millar C, Schu P, Owen DJ, Robinson MS (2003). "Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin". Mol. Biol. Cell. 14 (6): 2385–98. doi:10.1091/mbc.E02-11-0735. PMC 194887. PMID 12808037.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Hirst J, Borner GH, Harbour M, Robinson MS (2005). "The aftiphilin/p200/gamma-synergin complex". Mol. Biol. Cell. 16 (5): 2554–65. doi:10.1091/mbc.E04-12-1077. PMC 1087257. PMID 15758025.
Theos AC, Tenza D, Martina JA, Hurbain I, Peden AA, Sviderskaya EV, Stewart A, Robinson MS, Bennett DC, Cutler DF, Bonifacino JS, Marks MS, Raposo G (2005). "Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes". Mol. Biol. Cell. 16 (11): 5356–72. doi:10.1091/mbc.E05-07-0626. PMC 1266432. PMID 16162817.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000274047 GRCh38: Ensembl release 89: ENSG00000275066, ENSG00000274047 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034940 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10477754-5] Page LJ, Sowerby PJ, Lui WW, Robinson MS (October 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin". J. Cell Biol. 146 (5): 993–1004. doi:10.1083/jcb.146.5.993. PMC 2169493. PMID 10477754.

[entrez-6] "Entrez Gene: AP1GBP1 AP1 gamma subunit binding protein 1".

[pmid12042876-7] Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (July 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nat. Struct. Biol. 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876. S2CID 42630285.

[pmid10814529-8] Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.

[pmid10777571-9] Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC (April 2000). "SCAMP1 function in endocytosis". J. Biol. Chem. 275 (17): 12752–6. doi:10.1074/jbc.275.17.12752. PMID 10777571.

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Function

Interactions

References

Further reading