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AKAP12

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AKAP12
Identifiers
AliasesAKAP12, AKAP250, SSeCKS, A-kinase anchoring protein 12
External IDsOMIM: 604698; MGI: 1932576; HomoloGene: 3740; GeneCards: AKAP12; OMA:AKAP12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005100
NM_144497
NM_001370346

NM_031185

RefSeq (protein)

NP_005091
NP_653080
NP_001357275

NP_112462

Location (UCSC)Chr 6: 151.24 – 151.36 MbChr 10: 4.22 – 4.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

A-kinase anchor protein 12, aka AKAP250, is an enzyme that in humans is encoded by the AKAP12 gene.[5][6]

Function

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The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinase A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[6]

Interactions

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AKAP12 has been shown to interact with Beta-2 adrenergic receptor.[7][8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131016Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038587Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nauert JB, Klauck TM, Langeberg LK, Scott JD (Mar 1997). "Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein". Curr. Biol. 7 (1): 52–62. Bibcode:1997CBio....7...52N. doi:10.1016/S0960-9822(06)00027-3. PMID 9000000. S2CID 18843778.
  6. ^ a b "Entrez Gene: AKAP12 A kinase (PRKA) anchor protein (gravin) 12".
  7. ^ Fan G, Shumay E, Wang H, Malbon CC (Jun 2001). "The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization". J. Biol. Chem. 276 (26): 24005–14. doi:10.1074/jbc.M011199200. PMID 11309381.
  8. ^ Shih M, Lin F, Scott JD, Wang HY, Malbon CC (Jan 1999). "Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin". J. Biol. Chem. 274 (3): 1588–95. doi:10.1074/jbc.274.3.1588. PMID 9880537.
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Further reading

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