3,5-Difluoro-4-hydroxybenzylidene imidazolinone
Appearance
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IUPAC name
(5Z)-5-[(3,5-Difluoro-4-hydroxyphenyl)methylene]-3,5-dihydro-2,3-dimethyl-4H-imidazol-4-one[2]
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Other names
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Identifiers | |
3D model (JSmol)
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PubChem CID
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Properties | |
C12H10F2N2O2 | |
Molar mass | 252.221 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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3,5-Difluoro-4-hydroxybenzylidene imidazolinone or DFHBI[2] is an imidazolinone fluorophore used in various biochemical studies. The benzene ring of DFHBI can freely rotate around the single bond but when it is fixed in planar conformation, DFHBI fluoresces.[1] It is a synthetic analog of the GFP fluorophore.
References
[edit]- ^ a b Dou, Jiayi; Vorobieva, Anastassia A.; Sheffler, William; Doyle, Lindsey A.; Park, Hahnbeom; Bick, Matthew J.; Mao, Binchen; Foight, Glenna W.; Lee, Min Yen; Gagnon, Lauren A.; Carter, Lauren (September 2018). "De novo design of a fluorescence-activating β-barrel". Nature. 561 (7724): 485–491. Bibcode:2018Natur.561..485D. doi:10.1038/s41586-018-0509-0. ISSN 0028-0836. PMC 6275156. PMID 30209393.
- ^ a b "DFHBI 1241390-29-3". Sigma Aldrich. Archived from the original on 2022-01-13.